Artichoke (& Artichoke Extract): Is It Really Good For The Liver?

Claim

Artichoke (& Artichoke Extract) is good for the liver.

Verdict

Maybe

There are studies to support the claim that artichoke (& artichoke extract) is good for the liver but more robust research is needed to corroborate these findings.

Origin

A post on liversupport.com stated that artichoke can help protect the liver from damage caused by known toxins. There is growing evidence in the both the scientific and medical literature to support this claim.

One of the earliest studies on the protective effects of artichoke on the liver dates back to research done on rats in 1966 (1). More recently, studies in rats showed that artichoke offers some protection against paracetemol induced liver injury (2).

Apart from rat studies, there are a growing number of studies looking at the hepatoprotective effects of artichoke in humans.  A single case report showed a beneficial effect of artichoke on reversing liver damage in a patient who had been prescribed a single dose of the antifungal agent fluconazole (3).

There is growing interest in the role of artichoke in the treatment of patients with hepatitis C.  One laboratory based study showed that artichoke extract inhibited early steps in the life cycle of all genotypes (strains) of hepatitis C  (4).  Data from a small clinical study showed that artichoke cleared the hepatitis C virus in 12 of 15 patients and also normalized liver function tests in these patients (5).

The study did not have a control group.  An earlier study in 17 patients with hepatitis C did not show any benefit of artichoke extract on either the hepatitis C viral load or liver function tests (6).  It is unclear from the literature why these two studies produced contradictory results and more research is needed to clarify this issue.

In a randomized double blind clinical trial, 60 consecutive patients suffering non-alcoholic fatty liver disease were randomly assigned to receive artichoke extract tablets  at a dose of 2700 mg extract of the herb or placebo as for 60 days.  Patients receiving the artichoke extract were noted to have significant improvements in their liver tests as compared to the patients in the control group (7).

Artichoke plays a complex (and not yet fully understood) role in the liver. Liver damage caused by ingestion of artichoke has been reported (8).

In summary , experimental and clinical studies have verified that artichoke can be good for the liver (9). There is not enough research to know exactly how best to use artichoke for different liver conditions or the long term safety of artichoke supplementation (10).

References

  1. Effects of Cynara scolymus extracts on the regeneration of rat liver. Maros, T, et al. 1. Arzneimittelforschung 1966; 16(2): 127–29
  2. Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats. El Morsy EM, Kamel R.Pharm Biol. 2015 Feb;53(2):167-73. doi: 10.3109/13880209.2014.913066. Epub 2014 Sep 22.
  3. The possible efficacy of artichoke in fluconazole related hepatotoxicity.  Kurt H, Toprak O, Bülbül E. Case Reports Hepatol. 2014;2014:697359. doi: 10.1155/2014/697359. Epub 2014 Sep 3.
  4. Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke. Elsebai MF, Koutsoudakis G, Saludes V, Pérez-Vilaró G, Turpeinen A, Mattila S, Pirttilä AM, Fontaine-Vive F, Mehiri M, Meyerhans A, Diez J. J Virol. 2015 Dec 9;90(4):1918-30. doi: 10.1128/JVI.02030-15.
  5. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. Food Funct. 2016 Jul 13;7(7):3006-16. doi: 10.1039/c6fo00656f.
  6. Artichoke leave extract for chronic hepatitis C – a pilot study. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Phytomedicine. 2009 Sep;16(9):801-4. doi: 10.1016/j.phymed.2009.03.007. Epub 2009 May 8.
  7. The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A. Int J Hepatol. 2016;2016:4030476. doi: 10.1155/2016/4030476. Epub 2016 May 11.
  8. Acute hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol). Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. Gastroenterol Clin Biol. 2007 Nov;31(11):1039-40. French. No abstract available.
  9. Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. Ben Salem M, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM. Plant Foods Hum Nutr. 2015 Dec;70(4):441-53. doi: 10.1007/s11130-015-0503-8. Review.
  10. Efficacy of different Cynara scolymus preparations on liver complaints. Speroni E, Cervellati R, Govoni P, Guizzardi S, Renzulli C, Guerra MC. J Ethnopharmacol. 2003 Jun;86(2-3):203-11.
Summary
Artichoke (& Artichoke Extract): Is It Really Good For The Liver?
Article Name
Artichoke (& Artichoke Extract): Is It Really Good For The Liver?
Author
Healthy But Smart

1 Comment Artichoke (& Artichoke Extract): Is It Really Good For The Liver?

  1. Hammond Robert Kobina

    I read with interest your 10 points all disapproving the so called benefits of drinking warm water with lemon juice. May I know whether in your research you did find at least one benefit of lemon juice?

    Reply

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