Does Moringa Oleifera Have Health Benefits? The Research Examined

Introduction

I am on holidays in the beautiful Sonoran desert, Arizona and was told by the hotel gardener that many of the locals eat Moringa leaves to manage pre-diabetes and diabetes. Always the researcher (even on vacation), I had to try the leaves for myself. The leaves tasted pleasant enough but do they actually have any health benefits?

A quick (covert) poolside internet search on my cell-phone confirmed that the blogosphere agrees with the gardeners claim that Moringa has anti-diabetic properties. Additionally, Moringa is purported to offer over 300 medical benefits including anti-bacterial, anti-inflammatory, anti-ulcer, anti-cancer and anti-asthma properties.

Even on vacation, I simply have to do my own research. It is a pity that the uncutblogosphere is so unreliable and predictably inaccurate. Even worse, the viral nature of the internet means that misinformation can spread so easily.

Bottom line: I had to do my own research. Feeling a little guilty, I sat under the shade of a large Moringa tree and checked out its credentials as a natural superfoodand miracle tree.

What Is Moringa?

Moringa (aka horse radish/drumstick tree) is an edible plant which is native to Asia and Africa. So how exactly was I enjoying the shade of a Moringa in Arizona? It seems that British colonists brought the tree from India to Africa and Jamaica. Thanks to the globalization, Moringa has been planted around the world and is now cultivated worldwide.

India is the largest producer of Moringa worldwide with an annual production of 1.3 million tons. There are 13 different species of Moringa with Moringa oleifera being the most used and most studied species. There is high heterogenity in both the form and yield of Moringa which is very relevant when it comes to interpreting the literature on the subject as we will see.

Moringa is a hardy tree which requires less than 800mm per year of irrigation. It grows quickly and can reach heights of 12m in just a few years. On the plus side, this means that Moringa is seen as a reliable crop but on the negative side, it is discriminated in poorer countries as a just famine food.

Historically, Moringa was used back in ancient Egypt as a cosmetic and is widely used in Ayurvedic or traditional Indian medicine. Interest in Moringa peaked in the 1990s with the recognition that Morigna was useful for purifying water. Moringa contains charged particles which repel similarly charged particles in natural water and thus acts as a natural filtration system. From there, interest in the tree grew. Fast forward a decade to 2001 when an international conference on Moringa was held in Tanzania. There are now a number of research centres focusing on Moringa (India, Taiwan, Zambia and the Philippines).

There are three main parts of the tree: leaves, seeds and flowers.

Seven categories of use (food, medicine, fodder, fencing, firewood, gum and coagulant) have been recorded for Moringa oleifera.

Generally speaking, the leaves and seeds of the tree are used as food, while the leaves, bark and root are used as medicinal products.

Looking in more detail at the medicinal uses of Moringa, we find that the:

leaves are used for malaria, typhoid, parasitic infections, arthritis, hypertension, diabetes, immune boosting, cardiac stimulation, contraception and as a lactation aid

seeds are used for stomach ulcers, toothache, poor vision, hemorrhoids and as biomass for biodiesel production

roots are used as a sex enhancer

flowers are used as an aphrodisiac, to treat hysteria and enlargement of the spleen.

Quite the list!

There are 6000 Moringa related products for sale on Amazon. Moringa derivative products include powder, seeds, capsules, tea and oil. Costs run as high as $1 per oz for fine powder and $5 per fluid oz for Moringa oil.

Moringa leaves contain a multitude of compounds including vitamins (E and C), minerals (calcium, phosphorus, potassium, sulphur, zinc, copper, manganese, iron, selenium), protein, fibre, lysine, tannins, cellulose, polyphenols and quercetin.

Some blogs have claimed that Moringa leaves contain seven times the amount of vitamin C as orangesand four times the amount of vitamin A as carrots. Really?

Lets start with vitamin A.

Fresh Moringa leaves contain between 11,000 IU and 23,000 IU of vitamin A. They also contain carotenoids with pro-vitamin A activity. The carotenoid content varies between and 6.6 and 6.8mg/100g for fresh leaves of Moringa and 17.6 to 39.6mg/100g for dried leaves. Overall beta carotene is more concentrated in the dried leaves (1).

This is different to vitamin C where the vitamin C content in fresh leaves is higher than in dried leaves as vitamin C is sensitive to heat and oxygen. Typical levels of vitamin C in fresh leaves are 200mg/100 g but drops to 18.7mg/100g for dried leaves (to put this into context, fresh oranges contain 37.4mg/100g of vitamin C). Some studies have found no vitamin C at all in dried Moringa leaves (1).

What does all this mean in simple English? Hard to know exactly.

  1. There is huge variability in the content of different Moringa preparations which makes it very difficult to make any generalization or meaningful comparisons to other nutrient dense foods. Different plant genetics, environmental conditions, extraction, drying and analytical methods account for the wide variability noted between different Moringa preparations. Some Moringa preparations may be a rich source of vitamin C and some are not. The uncertainly makes it hard to rely on Moringa for vitamin C. Anyway, looking at the tree above me, only a giraffe could eat 100 gm of leaves. It is far easier to eat 100g of fresh orange than fresh Moringa leaves.
  2. Vitamin A deficiency is prevalent in many developing countries and accounts for both maternal and child mortality. Vitamin A deficiency is not an issue for the general population in the developed world which undermines the value of Moringa for many of us.

Is There Any Research?

There are a total of 740 published papers on Moringa but this includes just 5 human clinical studies. To out this into context, spirulina has twice many papers and 50 human clinical trials.

Additionally, only 12 studies include genetic characterization of the Moringa species used.

Is Moringa an Anti-Inflammatory? Does it have Antioxidant properties?

There are no human clinical trialls looking at the anti-inflammatory properties of Moringa. My PubMed search for clinical studies of the anti-inflammatory effects of Moringa did show up a study in cross bred Xhosa lop-eared castrated goats. If I ever have a cross bred Xhosa lop-eared castrated goatjoin my practice, I will be sure to check that study. Seriously, who comes up with studies like that?

While there are no human clinical trials, there are a number of in vitro, in vivo and ex vivo studies of interest.

Studies done in vitro show that Moringa leaves significantly decrease gene expression and production of inflammatory markers in macrophage white cells. (2)

Another study identified a chitin-binding protein (Mo-CBP4) from M. oleifera seeds and showed that it exhibits anti-inflammatory and anti-nociceptive properties (3).

Moringa also contains kaempferol which is emerging as an anti-oxidant/anti-inflammatory of interest (one to watch) in the medical literature (4).

An ex-vivo study (cells taken from humans) showed that Moringa inhibited oxidative modification of human plasma cells (5)

Bottom Line: Laboratory studies confirm the anti-inflammatory and anti-oxidant properties of Moringa but this has yet to be replicated in human clinical trials.

Does it Balance Hormones?

A study from India found that Moringa leaf extract was beneficial in the reversal of hyperthyroidism in Swiss rats (6). Interestingly the effects of Moringa was more pronounced in female rats and at lower doses (175mg/kg versus 350 mg/kg). At this stage it is hard to know the significance of these two findings but it definitely suggests that there is a lot more to this story than just simple anti-thyroid effects.

Another study in rats showed that Moringa leaf exerted an anti-fertility effect in female rats primarily by modulating the expression of estrogen and progesterone (7).

The fertility story does not end there. Sixty male Wistar rats participated in a study to look at the effects of mobile phone electromagnetic radiation induced infertility (8). This study showed that testicular injury due to chronic exposure to electromagnetic radiation can be prevented by Moringa oleifera leaf extract.

Bottom Line: Laboratory studies suggest that Moringa influences hormones but it is very unclear as to what specific role Moringa plays. Much more research is needed to untangle the hormonal role of Moringa before it would be ready for human studies. Only then could recommendations be made on the hormonal effects of this tree.

Does It Slow the Effect of Ageing? Enhance brain health?

An experimental mouse model study showed that Moringa oleifera shows potent anti-inflammatory activity in the treatment of murine subacute Parkinson’s Disease (9).

Another study relevant to Moringa and ageing comes from Thailand (10).

Yes, just another animal model of dementia but interesting all the same. Rats with Parkinson’s induced by AF64A (a choline toxin) were given Moringa. Spatial memory was examined in a  water maize. The rats were then sacrificed and the brains were examined histologically.

This study demonstrated a memory enhancing effect of M. oleifera leaf extract. It was thought that this might occur partly via decreased oxidative stress and also via enhanced cholinergic function. The authors concluded that the results suggest that M. oleifera leaves extract possesses the neuroprotective and memory enhancing effects.

Finally, there is growing interest in the use of Moringa as anti-ageing face creams (12).

Bottom Line: Moringa is no more than a potential anti-ageing compound at this stage.

Does it Improve Digestive Health?

The science here is very limited again.

Moringa seed extract was shown to be effective at treating experimental colitis in male Wisteria rats (13).

As an aside, there is also interest in using Moringa gum as a carrier for colon specific drug delivery (14).

Bottom Line: There is no science to support the claim that Moringa improves digestive health.

Does It Affect Blood Sugar? Help With Diabetes?

Finally, we get a clinical study in real humans. A study in ten healthy volunteers in Thailand measured the insulin response to increasing doses of Moringa (14). There was a statistically significant reduction in the insulin secretion rate following 4gm of Moringa as compared to baseline.

It is worth noting that these volunteers were young aged 29+/- 5 years and had a low BMI of 20. As such they are not representative of the demographic of the population of interest. It is also hard to rely too much on a study with a sample size of just 10.

Bottom Line: There is a single healthy volunteer study looking at the anti-diabetic effects of Moringa. Further studies in patients with the metabolic syndrome+/diabetes are needed.

Is it Good For Your Skin?

There are two studies of interest here in addition to the anti-ageing study mentioned above.

The first study from Pakistan enrolled 11 healthy volunteers aged 20-35 years old who applied a water-cream mixture of Moringa to their cheeks twice daily for 12 weeks. The study found that there was a significant improvement in skin hydration (15).

The second study from the same research group looked at 11 healthy volunteers who again applied Moringa cream twice daily to the cheeks for 3 months.  Skin re-vitalizing parameters (surface, texture and volume) and evaluation of living cells was done using skin topography. The study  found a gradual decrease in roughness and scaliness along with a gain in collagen (16).

Bottom Line: Small short term human clinical studies suggest that Moringa may be good for your skin. There are no large scale long term studies to back this up.

Does it Stabilize Mood?

When it comes to mood disorders, most people think of anxiety and depression.

There are no studies of Moringa in anxiety.

There is a study of Moringa in a depressed mouse model (17)

Depressed Swiss albino mice were randomized to either a control group, low dose Moringa +/- Prozac or high dose Moringa +/- Prozac.

The animals were tested using behavioral models of depression, such as forced swim test (FST), tail suspension test (TST), and locomotor activity test (LAT). The study suggested that low dose Moringa extract plus 10 mg Prozac positively affected the mood of these animals.

(The ethical part of me wonders if these depressed rats were given the successful Moringa plus Prozac cocktail (or maybe even some Toblerone) after the study ended?).

Bottom line: There are no human studies to support the mood enhancing effects of Moringa.

Is Moringa Safe?

A number of clinically relevant side effects have been reported with Moringa.

Occupational asthma has been described with Moringa (18).

Moringa  inhibits the activity of the cytochrome P450 3A4 system in the liver (19) .This raises the possibility of clinically significant drug interactions with medications metabolized  by this system such as anti HIV drugs, anti-TB drugs and some BP medications. The leaves are more potent inhibitors of the cytochrome system as compared to the roots.

Moringa oleifera is safe at levels 1,000 mg/kg body weight but has been shown to be genotoxic at supra-supplementation levels of 3,000 mg/kg body weight (20).

Conclusion

The most comprehensive (44 page) review on Moringa published in 2015 in the International Journal of Molecular Science concluded that There are too few studies on humans to recommend Moringa leaves as medication in the prevention or treatment of diseases (1).  That about sums it up.

I feel a little guilty. I have enjoyed the shade of this beautiful tree and am now effectively dissingit. It feels especially bad as I read The Secret Lives of Treeson the plane ride here which made a compelling case that trees are intelligent sentient beings. So just in case and by way of apology, here goes:

Moringa exemplifies many of the problems with research on herbal medicines.

Firstly, there are relatively few studies to look at. This is unlikely to change given the fact that producers of Moringa cannot use any positive results in their labeling or marketing. This is a major disincentive to funding any studies and especially expensive human clinical studies.

Secondly, Moringa is not a single entity. There are 13 species of Moringa. Moringa is a tree with flowers, leaves and seeds. That alone makes 39 variables of Moringa. Each part is a mixture of a huge range of compounds, each of which can have differing health or wellness effects. That makes for more Moringasthan we could ever study or make claims about.

Finally, there is huge variability in the constituents of Moringa from place to place, season to season and between producers depending on their manufacturing practices. This comes down to the fact that there are no effective regulations to standardize herbal products such as Moringa.

Taken together, it is pretty meaningless to say that Moringadoes anything.

References

  1. Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview. Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. Int J Mol Sci. 2015 Jun 5;16(6):12791-835. doi: 10.3390/ijms160612791. Review.
  2. Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Waterman C, Cheng DM, Rojas-Silva P, Poulev A, Dreifus J, Lila MA, Raskin I. Phytochemistry. 2014 Jul;103:114-122. doi: 10.1016/j.phytochem.2014.03.028. Epub 2014 Apr 1
  3. Purification of a chitin-binding protein from Moringa oleifera seeds with potential to relieve pain and inflammation. Pereira ML, de Oliveira HD, de Oliveira JT, Gifoni JM, Rocha Rde O, de Sousa Dde O, Vasconcelos IM. Protein Pept Lett. 2011 Nov;18(11):1078-85.
  4. Kaempferol, a potential cytostatic and cure for inflammatory disorders. Rajendran P, Rengarajan T, Nandakumar N, Palaniswami R, Nishigaki Y, Nishigaki I.Eur J Med Chem. 2014 Oct 30;86:103-12. doi: 10.1016/j.ejmech.2014.08.011. Epub 2014 Aug 5. Review.
  5. The in vitro  and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP, Phivthong-Ngam L, Ratanachamnong P, Srisawat S, Pongrapeeporn KU. J Ethnopharmacol. 2008 Mar 28;116(3):439-46. doi: 10.1016/j.jep.2007.12.010. Epub 2007 Dec 23.
  6. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Tahiliani P, Kar A Pharmacol Res. 2000 Mar;41(3):319-23.
  7. Antifertility profile of the aqueous extract of Moringa oleifera roots. Shukla S, Mathur R, Prakash AO. J Ethnopharmacol. 1988 Jan;22(1):51-62.
  8. The radioprotective effects of Moringa oleifera against mobile phone electromagnetic radiation-induced infertility in rats. Bin-Meferij MM, El-Kott AF. Int J Clin Exp Med. 2015 Aug 15;8(8):12487-97. eCollection 2015.
  9. The Isothiocyanate Isolated from Moringa oleifera Shows Potent Anti-Inflammatory Activity in the Treatment of Murine Subacute Parkinson’s Disease. Giacoppo S, Rajan TS, De Nicola GR, Iori R, Rollin P, Bramanti P, Mazzon E. Rejuvenation Res. 2017 Feb;20(1):50-63. doi: 10.1089/rej.2016.1828. Epub 2016 Jun 24.
  10. Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia. Sutalangka C, Wattanathorn J, Muchimapura S, Thukham-mee W. Oxid Med Cell Longev. 2013;2013:695936. doi: 10.1155/2013/695936. Epub 2013 Dec 23
  11. Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, Chen C, Murtaza G. Oxid Med Cell Longev. 2015;2015:709628. doi: 10.1155/2015/709628. Epub 2015 Sep 10. Review.
  12. Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats.Minaiyan M, Asghari G, Taheri D, Saeidi M, Nasr-Esfahani S. Avicenna J Phytomed. 2014 Mar;4(2):127-36.
  13. In vitro evaluation of Moringa oleifera gum for colon-specific drug delivery. Singhal AK, Jarald EE, Showkat A, Daud A. Int J Pharm Investig. 2012 Jan;2(1):48-51. doi: 10.4103/2230-973X.96926.
  14. Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects. Anthanont P, Lumlerdkij N, Akarasereenont P, Vannasaeng S, Sriwijitkamol A. J Med Assoc Thai. 2016 Mar;99(3):308-13.
  15. Ali A., Akhtar N., Khan M. S., et al. Moisturizing effect of cream containing Moringa oleifera (Sohajana) leaf extract by  biophysical techniques: in vivo evaluation. Journal of Medicinal Plants Research. 2013;7(8):386391.
  16. Ali A., Akhtar N., Chowdhary F. Enhancement of human skin facial revitalization by moringa leaf extract cream. Postepy Dermatologii i Alergologii. 2014;31(2):7176. doi: 10.5114/pdia.2014.40945
  17. Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine. Kaur G, Invally M, Sanzagiri R, Buttar HS. J Ayurveda Integr Med. 2015 Oct-Dec;6(4):273-9. doi: 10.4103/0975-9476.172384.
  18. Occupational asthma to “the miracle tree” (Moringa oleifera): first description. Poussel M, Penven E, Richard C, Jacquenet S, Chabot F, Paris C. J Allergy Clin Immunol Pract. 2015 Sep-Oct;3(5):813-4. doi: 10.1016/j.jaip.2015.05.016. Epub 2015 Jun 25. No abstract available.
  19. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. J Infect Dev Ctries. 2008 Oct 1;2(5):379-83.
  20. Asare GA, Gyan B, Bugyei K, et al. Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. Journal of Ethnopharmacology. 2012;139(1):265272. [PubMed]
Summary
Does Moringa Oleifera Have Health Benefits? The Research Examined
Article Name
Does Moringa Oleifera Have Health Benefits? The Research Examined
Author
Healthy But Smart

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